| Iowa State Cyclones vs. Tulsa Golden Hurricane | Iowa State Cyclones vs. Tulsa Golden Hurricane | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 09/01/2012 3:30 AM | Sep 01, 2012 TBA | View Tickets |
| Iowa Hawkeyes vs. Iowa State Cyclones | Iowa Hawkeyes vs. Iowa State Cyclones | Kinnick Stadium | Kinnick Stadium
Iowa City, IA | 09/08/2012 3:30 AM | Sep 08, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. Western Illinois Leathernecks | Iowa State Cyclones vs. Western Illinois Leathernecks | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 09/15/2012 3:30 AM | Sep 15, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. Texas Tech Red Raiders | Iowa State Cyclones vs. Texas Tech Red Raiders | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 09/29/2012 3:30 AM | Sep 29, 2012 TBA | View Tickets |
| TCU Horned Frogs vs. Iowa State Cyclones | TCU Horned Frogs vs. Iowa State Cyclones | Amon Carter Stadium | Amon Carter Stadium
Fort Worth, TX | 10/06/2012 3:30 AM | Oct 06, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. Kansas State Wildcats | Iowa State Cyclones vs. Kansas State Wildcats | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 10/13/2012 3:30 AM | Oct 13, 2012 TBA | View Tickets |
| Oklahoma State Cowboys vs. Iowa State Cyclones | Oklahoma State Cowboys vs. Iowa State Cyclones | Boone Pickens Stadium | Boone Pickens Stadium
Stillwater, OK | 10/20/2012 3:30 AM | Oct 20, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. Baylor Bears | Iowa State Cyclones vs. Baylor Bears | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 10/27/2012 3:30 AM | Oct 27, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. Oklahoma Sooners | Iowa State Cyclones vs. Oklahoma Sooners | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 11/03/2012 3:30 AM | Nov 03, 2012 TBA | View Tickets |
| Texas Longhorns vs. Iowa State Cyclones | Texas Longhorns vs. Iowa State Cyclones | Darrell K. Royal - Texas Memorial Stadium | Darrell K. Royal - Texas Memorial Stadium
Austin, TX | 11/10/2012 3:30 AM | Nov 10, 2012 TBA | View Tickets |
| Kansas Jayhawks vs. Iowa State Cyclones | Kansas Jayhawks vs. Iowa State Cyclones | Memorial Stadium - KS | Memorial Stadium - KS
Lawrence, KS | 11/17/2012 3:30 AM | Nov 17, 2012 TBA | View Tickets |
| Iowa State Cyclones vs. West Virginia Mountaineers | Iowa State Cyclones vs. West Virginia Mountaineers | Jack Trice Stadium | Jack Trice Stadium
Ames, IA | 11/24/2012 3:30 AM | Nov 24, 2012 TBA | View Tickets |